Colonic London

Yokneam, Israel - (Marketwire - November 23, 2009) - Given Imaging Ltd. (NASDAQ: GIVN), the global leader in capsule endoscopy, today announced the launch of its second-generation PillCam ® COLON Capsule Conference 2009 Gastro taking place in London. Like other endoscopes Given Imaging capsule, PillCam SB and PillCam ESO ® ®, PillCam COLON could be more user friendly for the patient for imaging the gastrointestinal tract.

This advanced PillCam contains proprietary, innovative technologies, including intelligent functionality and superior imaging, designed to provide physicians with a clear and accurate picture of colon polyps and interest. Having received the CE Mark in September 2009, Given Imaging will begin to market PillCam COLON ® 2 in some European countries with availability throughout Europe, scheduled for mid-2010.

The Company also announced that independent researchers have presented the results of a feasibility study-98 patients. The investigators concluded that PillCam COLON 2 is a safe and effective method to visualize the colon and detect polyps in the colon. An article that discusses the study was accepted for the December 2009 edition of the journal Endoscopy.

High sensitivity and specificity

Results of the study comparing PillCam COLON with colonoscopy 2, showed a sensitivity of 89 percent and a specificity of 76 percent in detecting polyps greater than or equal to 6 mm and a sensitivity of 88 percent and specificity of 89 percent in the detection of polyps greater than or equal to 10 mm. Conducted by clinicians in five hospitals in Israel, the study assessed the performance of PillCam COLON 2 in 98 patients who had risk or early signs of colon pathology. Like other capsules Given Imaging PillCam, PillCam COLON 2 does not require the use of sedation, intubation or insufflation of air during the procedure offers physicians and patients a convenient way to visualize the colon.

"The data of PillCam COLON 2 are promising and suggest it may be a safe, minimally invasive option for visualizing the colon in patients who do not want a colonoscopy, an examination has been incomplete, or those for whom colonoscopy is indicated-cons. We are encouraged by the data, which suggest that PillCam COLON 2 could be a reliable alternative to conventional colonoscopy for these patients, "said Professor Rami Eliakim, president of medicine and Director of Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel.

New Features 2 PillCam COLON

PillCam COLON revolutionary technology available in 2 and the PillCam Platform allows an option more convenient for the patient to visualize the colon. New features include:

Smart feature

bidirectional communication between 2 and PillCam Colon DataRecorder allows tracking the movement of the capsule in the gastrointestinal tract and the rate of image capture can be adjusted to optimize coverage of colon tissue.

- Adaptive Frame Rate adjusts the rate of image capture from four
frames per second to 35 frames per second, allowing the creation of a
smooth video, continues.

- Estimated size of polyps is a new research tool that allows
clinicians to assess the size of polyps.

Superior imaging compared with Cola³n 1

- Advanced optics for enhanced image quality and detection of polyps.

- 172 ° field of view of each imager offers a 360 ° angle at the
colon.

In addition, Given Imaging has integrated other features in the software RAPID ® to further streamline workflow of office.

"PillCam COLON 2 incorporates the expertise accumulated in the first PillCam COLON and over 1,000,000 PillCam ® capsule ingestion in the world," said Homi Shamir, president and CEO of Given Imaging. "Despite the small size o.